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KMID : 0848120160410010045
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International Journal of Oral Biology
2016 Volume.41 No. 1 p.45 ~ p.51
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Rutin induces autophagy in cancer cells
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Park Mi-Hee
Kim Se-Yeon
Song Yu-Ri
Kim Su-mi
Kim Hyung-Joon
Na Hee-Sam
Chung Jin
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Abstract
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Rutin (3,3′,4′,5,7-pentahydroxyflavone-3-rhamnoglucoside)is a bioactive flavonoid from the plant kingdom. Rutin has been studied as potential anticancer agent due to its wide range of pharmacological properties including antioxidative, anti-inflammatory and anticancer. Autophagy is a conserved intracellular catabolic pathway to maintain cell homeostasis by formation of autophagosome. Processing of autophagy involves various molecules including ULK1 protein kinase complex, Beclin-1?Vps34 lipid kinase complex, ATG5, ATG12, and LC3 (light chain 3). Cargo-carried autophagosomes fuse with lysosomes resulting in autophagolysosome to eliminate vesicles and degrade cargo. However, the actions of rutin on autophagy are not clearly understood. In this study, we analyzed the effect of rutin on autophagy and inflammation in cancer cell lines. Interestingly, rutin induced autophagy in leukemia (THP-1), oral (CA9-22), and lung (A549) cell lines. TNF-α, key modulator of inflammation, was upregulated by inhibition of rutin-induced autophagy. Taken together, these data indicated that rutin induced autophagy and consequently suppressed TNF-α production.
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KEYWORD
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Rutin , autophagy , cancer cell
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